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Fixed drug eruption in a cribriform pattern: an atypical presentation.

Mahesh Mathur¹, Neha Thakur¹, Sandhya Regmi¹

¹Department of Dermatology, College of Medical Sciences Teaching Hospital, Bharatpur, Nepal.

Skin Health and Disease

|March 24, 2025

Summary

Fixed drug eruption (FDE) is a specific drug reaction that reappears in the same spot. Researchers report a rare cribriform pattern of FDE in a pediatric patient.

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Area of Science:

Dermatology
Immunology
Pharmacology

Background:

Fixed drug eruption (FDE) is a distinct adverse drug reaction.
It is characterized by recurrent, well-defined lesions at the same site upon re-exposure to causative drugs.
FDE is a type IV hypersensitivity reaction mediated by CD8+ T cells.

Observation:

The case involves a 12-year-old boy presenting with FDE.
The observed FDE exhibited a cribriform pattern.
This specific pattern has not been previously described in medical literature.

Findings:

The study identifies and describes a novel cribriform pattern of fixed drug eruption.
This expands the known clinical presentations of FDE.
The reaction recurs in the same location and resolves with hyperpigmentation.

Implications:

Recognition of the cribriform pattern can aid in earlier diagnosis of FDE.
This finding contributes to the understanding of FDE variants and their clinical spectrum.
Further research may explore the specific immunological mechanisms underlying this pattern.