Identifying reversible psychiatric dementia mimics in new memory clinic outpatients

Timely identification of reversible conditions that mimic dementia is critical in memory clinic practice. However, psychiatric conditions as potential dementia mimics have not been studied as thoroughly as neurological ones, and detailed data on their reversibility remain limited.

To identify reversible psychiatric dementia mimics.

A retrospective chart review was conducted on 749 new outpatients to investigate etiologies, progression rates, a neuropsychological assessment, cognitive and functional levels, and potential reversibility, categorized by psychiatric and neurological conditions. Cases showing cognitive reversibility following treatment were also identified. Comparisons were made based on the presence or absence of potential reversibility, as well as actual reversibility.

Among the 749 individuals, 121 (16.2%) had potentially reversible conditions: 75 psychiatric and 46 neurological. Psychiatric conditions included depression, schizophrenia and delusional disorders, developmental disorders, alcohol use disorder, and dissociative and anxiety disorders. Compared to individuals without potentially reversible conditions, individuals with psychiatric conditions were younger, had a faster progression rate, and demonstrated higher cognitive function. Of the individuals who had mild cognitive impairment or dementia mimic, 6 (0.9%) showed complete cognitive resolution (3 cases) or partial cognitive improvement (3 cases). These 6 cases included two individuals with psychiatric conditions manifesting psychotic features.

While rare, reversible psychiatric dementia mimics highlight the importance of comprehensive evaluations in memory clinics, particularly for younger individuals experiencing rapid cognitive decline. The infrequency of reversibility may reflect a strong association between these potentially reversible conditions and dementia risk factors, or their role as prodromes of dementia itself.