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Exercise Delays Brain Ageing Through Muscle-Brain Crosstalk
Shirin Pourteymour1, Rakesh Kumar Majhi2,3, Frode A Norheim1
1Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Cell Proliferation
|March 24, 2025
Summary
Regular exercise benefits brain health by slowing ageing and enhancing cognitive function. Skeletal muscle communicates with the brain, influencing neuroinflammation and myelination for better overall brain well-being.
Area of Science:
- Neuroscience and Exercise Physiology
- Muscle-Brain Interactions
- Aging and Cognitive Health
Background:
- Cognitive decline and dementia risk increase with age.
- Exercise offers benefits for cognitive function, mood, sleep, and well-being.
- Understanding exercise's role in healthy brain aging is crucial.
Purpose of the Study:
- To review the link between exercise and brain health.
- To explore skeletal muscle's influence on the brain via muscle-brain crosstalk.
- To examine exercise effects on neuroinflammation and neuronal myelination.
Main Methods:
- Literature review focusing on exercise, brain health, and muscle-brain communication.
- Analysis of myokines (e.g., brain-derived neurotrophic factor, cathepsin B) involved in crosstalk.
- Examination of evidence regarding exercise's impact on neuroinflammation and central nervous system myelination.
Main Results:
- Exercise positively influences brain health through specific pathways.
- Myokines mediate communication between skeletal muscle and the brain.
- Exercise may counteract age-related neuroinflammation and support myelination.
Conclusions:
- Exercise is a potent strategy for promoting healthy brain aging.
- Muscle-brain crosstalk, mediated by myokines, is key to exercise's neurological benefits.
- Further research into exercise's effects on myelination is warranted for cognitive health.
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