Related Experiment Video
Updated: May 20, 2025
Isolation, Characterization, and Total DNA Extraction to Identify Endophytic Fungi in Mycoheterotrophic Plants
Published on: May 5, 2023
New polyketides from the mangrove-associated endophytic fungus Phomopsis sp. DHS-11
Zhi-Kai Guo1, Bi-Ting Chen1,2, Dan-Dan Chen2
1Hainan Key Laboratory of Tropical Microbe Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences & Key Laboratory for Biology and Genetic Resources of Tropical Crops of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Haikou 571101, China.
Abstract:
Chemical investigation of the mangrove-derived fungus Phomopsis sp. DHS-11 led to the isolation of three new pyrone derivatives (1-3), and a new natural product (4). Their structures were identified by NMR spectroscopy and mass spectrometry. The configurations for the new pyrone derivatives were tentatively solved by comparison of 13C NMR data and analysis of the coupling constants and NOESY correlations. Compounds 2 and 3 exhibited significant cytotoxicity against HepG2 with IC50 values of 4.66 ± 0.35 µM and 6.07 ± 0.48 µM, respectively. Compound 3 showed moderate cytotoxicity against Hela cells with IC50 value of 20.2 ± 4.93 µM.
More Related Videos
15:14Establishing Fungal Entomopathogens as Endophytes: Towards Endophytic Biological Control
Published on: April 11, 2013
09:08From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
