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The Structure and Functional Changes of Thyroid in Severe Acute Pancreatitis Rats
1Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. Department of Pharmacy, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. shouyipwx@hotmail.com.
Severe acute pancreatitis (SAP) causes significant thyroid damage, lowering key thyroid hormones and calcium levels. This study reveals SAP
Area of Science:
- Endocrinology
- Gastroenterology
- Pathology
Background:
- Severe acute pancreatitis (SAP) is a critical condition linked to metabolic disturbances, hypocalcemia, and multi-organ dysfunction.
- Thyroid dysfunction is a potential complication of SAP, impacting overall patient outcomes.
Purpose of the Study:
- To investigate the ultrastructural and functional alterations in the thyroid gland during severe acute pancreatitis in a rat model.
- To establish a foundational understanding for managing thyroid complications in human SAP patients.
Main Methods:
- Utilized a rat model of severe acute pancreatitis (SAP) with a control group (n=64).
- Assessed pancreatic enzymes, thyroid hormones (T3, T4), and calcium levels.
- Conducted histopathological evaluations and observed morphological changes via light and transmission electron microscopy (TEM).
Main Results:
- SAP rats exhibited significantly reduced serum triiodothyronine (T3), tetraiodothyronine (T4), and calcium (Ca2+) levels compared to controls (P<0.05).
- Calcitonin (CT) levels were significantly elevated in the SAP group (P<0.05).
- TEM revealed severe, time-dependent structural damage to the thyroid gland in SAP rats.
Conclusions:
- Severe acute pancreatitis induces significant thyroid injury, affecting both structure and function.
- Thyroid damage may exacerbate pancreatitis through a feedback mechanism, intensifying the inflammatory response.
- Findings offer theoretical insights for basic research into SAP and its systemic effects.
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