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Factor X Concentrate Treatment Schedule and Dosing in Acquired FX Deficiency
Andrew Ross1, Rebecca J Shaw1,2, Louise Garth1
1Liverpool University Hospital NHS Foundation Trust, Liverpool L7 8XP, UK.
Background:
Acquired factor X (FX) deficiency is a rare condition that can cause life threatening bleeding. Here we outline a successful management strategy for gastrointestinal bleeding (GI) using human FX concentrate.
Case Description:
A 61-year-old male presented with upper GI bleeding and a prolonged prothrombin time. Investigations demonstrated an acquired FX deficiency (determined to be secondary to AL amyloidosis).
Results:
Treatment with FX concentrate to maintain trough FX levels >20% resulted in successful cessation of bleeding symptoms, and levels >50% facilitated urgent invasive procedures.
Conclusions:
This case report adds valuable insight into the management of this rare condition, and how best to utilize FX concentrates in acquired FX deficiency.
