Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

30.8K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
30.8K
Gene-Environment Interactions01:20

Gene-Environment Interactions

227
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
227
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

6.4K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.4K
Human Genetics01:28

Human Genetics

506
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
506
Translation01:31

Translation

14.3K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
14.3K
Epistasis01:39

Epistasis

44.6K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
44.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis, Characterization, and Photocatalytic Performance of Phosphorus-Functionalized Triazatriangulenium Derivatives.

Organic letters·2026
Same author

TRMT6/61A-mediated m <sup>1</sup> A methylation facilitates human pre-tRNA maturation and prevents surveillance by XRN2.

bioRxiv : the preprint server for biology·2026
Same author

CuCo<sub>2</sub>S<sub>4</sub>/COFs composite to efficiently activate peroxymonosulfate: oxytetracycline degradation, reactive oxygen species, degradation routes and ecotoxicity.

Environmental research·2026
Same author

Chemical-Modification-Triggered Emergence of Phosphorescence in <i>o</i>-Carborane-Fused Benzophospholes.

Organic letters·2026
Same author

Ambiphilic Phosphinidene-Enabled Regioselective Ring-Opening of Epoxides.

Organic letters·2026
Same author

Strengthening influence of atmospheric rivers on global snow depth dynamics.

Nature communications·2026

Related Experiment Video

Updated: May 20, 2025

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

22.8K

Environmental Exposure, Epitranscriptomic Perturbations, and Human Diseases.

Songbo Wei1, Huan-Yu Tao1, Zheng Duan1

  • 1Department of Chemistry, University of California, Riverside, California 92521-0403, United States.

Environmental Science & Technology
|March 24, 2025
PubMed
Summary
This summary is machine-generated.

Environmental exposures can alter RNA modifications, impacting gene expression and disease. Understanding these epitranscriptomic changes is crucial for human health and developing new biomarkers.

Keywords:
RNAenvironmental exposureepitranscriptomicsgene expressionmetalloproteinpost-transcriptional modification

More Related Videos

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

616
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.3K

Related Experiment Videos

Last Updated: May 20, 2025

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

22.8K
Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

616
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.3K

Area of Science:

  • Epitranscriptomics: The study of dynamic RNA modifications and their regulatory proteins.

Background:

  • Environmental agents can alter RNA chemical modifications, influencing gene expression and disease.
  • Mechanisms by which environmental exposure affects RNA modification-associated proteins (RWE proteins) are not well understood.

Purpose of the Study:

  • To review current knowledge on how environmental exposure impacts the epitranscriptome.
  • To discuss the role of epitranscriptomic alterations in diseases like neurodegeneration and cancer.
  • To explore the potential and challenges of using RNA modifications as biomarkers for environmental exposure.

Main Methods:

  • Review of existing literature on environmental exposure and epitranscriptomics.
  • Focus on dynamic changes in RNA modifications and RWE proteins.
  • Discussion of multiomics approaches for integrated analysis.

Main Results:

  • Environmental exposure significantly alters the epitranscriptome.
  • Epitranscriptomic changes are implicated in neurodegeneration and cancer development.
  • RNA modifications show potential as biomarkers for environmental exposure monitoring.

Conclusions:

  • Environmental factors critically influence RNA modifications and gene regulation.
  • Further research integrating multiomics is needed to understand epitranscriptomic alterations and their health impacts.
  • Harnessing epitranscriptomic insights can inform public health and environmental policies.