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Thrombopoietin production in a patient with chronic thrombocytopenia after plasma infusion

T P McDonald, M Miura, S Koizumi

    Thrombosis Research
    |May 15, 1985
    PubMed

    A thrombocytopoiesis-stimulating factor (TSF or thrombopoietin) was found to be significantly elevated in sera of a patient with chronic thrombocytopenia at one hour after infusion with fresh-frozen plasma (FFP). No detectable levels of TSF were found in the pre-infusion sera or in the infusate. At 2 hours post-infusion, TSF levels were decreased, and by 24 hrs the TSF titers were undetectable. Not only did FFP elevate TSF levels, but 6 days later significant increases in platelet counts were observed. This work confirms a previous finding of increased TSF levels following plasma infusion in a patient with similar clinical features and suggests that these patients lack a plasma factor that plays a critical role in TSF production.

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