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High Preference for Injectable Pre-exposure Prophylaxis among Young Women in Kenya.
Kidist Zewdie1,2, John Kinuthia3, Daniel Matemo3
1Department of Epidemiology, University of Washington, 3980 15th Ave NE, Seattle, WA, 98195, USA. kzewdie@gmail.com.
AIDS and Behavior
|March 24, 2025
Summary
Women in Kenya strongly prefer long-acting injectable pre-exposure prophylaxis (PrEP) over other HIV prevention methods. Understanding these preferences is crucial for the successful rollout of new, longer-acting HIV prevention options.
Area of Science:
- Public Health
- Infectious Disease Prevention
- Reproductive Health
Background:
- Longer-acting pre-exposure prophylaxis (PrEP) offers improved adherence for HIV prevention.
- Understanding user preferences is vital for the successful implementation of new PrEP products.
- Women in Kenya are a key demographic for HIV prevention strategies.
Purpose of the Study:
- To assess the preferences for different pre-exposure prophylaxis (PrEP) product types among sexually active, HIV-negative women in Kenya.
- To compare preferences between women with and without prior oral PrEP experience.
- To identify factors associated with a preference for injectable PrEP.
Main Methods:
- Cross-sectional study conducted in 12 family planning clinics in Kisumu, Kenya.
- Inclusion criteria: sexually active, HIV-negative women aged ≥15 years with characteristics associated with higher HIV acquisition risk.
- Data collected on demographics, PrEP experience, and preferences for oral, injectable, and vaginal ring PrEP modalities; statistical analyses included univariate and multivariate models.
Main Results:
- A total of 457 women were enrolled; 74% of those without prior PrEP experience preferred injectable PrEP, compared to 82% of recent oral PrEP users.
- Injectable contraceptives were used by 31% of participants.
- Perceived stigma was the only factor significantly associated with a preference for injectable PrEP (PR: 1.21).
Conclusions:
- Reproductive-age women in Kenya demonstrate a strong preference for long-acting injectable PrEP.
- Successful implementation of injectable PrEP requires consideration of user preferences and tailored delivery approaches.
- Future HIV prevention programs should prioritize user-centered product development and delivery strategies.
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