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Updated: May 20, 2025
07:41
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
2.4K
Genetic and Epigenetic Changes in Melanoma Progression: A TCGA-based Study
Yasemin Cakir1, Banu Lebe1,2, M Hasan Toper1,3
1Department of Molecular Pathology, Institute of Health Sciences.
Applied Immunohistochemistry & Molecular Morphology : AIMM
|March 24, 2025
Summary
Melanoma progression involves distinct genetic and epigenetic changes. Thin melanomas show immune response genes, while thick melanomas involve epidermis development, offering insights into melanoma advancement.
Area of Science:
- Oncology
- Genomics
- Immunology
Background:
- Melanoma progression is complex, influenced by genetic and epigenetic alterations.
- Understanding these molecular changes is crucial for diagnosis and prognosis.
Purpose of the Study:
- To investigate molecular mechanisms of melanoma progression.
- Compare genetic/epigenetic features between thin and thick melanomas using TCGA data.
Main Methods:
- Utilized TCGA melanoma dataset via cBioPortal.
- Analyzed mRNA expression and DNA methylation.
- Performed pathway enrichment (GO, KEGG) and protein-protein interaction network analysis.
Main Results:
- Identified 1001 differentially expressed genes between thin (≤1 mm) and thick (>1 mm) melanomas.
- Thin melanomas enriched in immune response pathways; thick melanomas in epidermis development.
- Identified ten key immunological hub genes (e.g., CD4, IFNG, PTPRC, CD8A).
Conclusions:
- Melanoma progression is characterized by shifts in gene expression related to immune response and epidermal development.
- Key immunological genes are implicated in melanoma advancement.
- Findings may guide future research on melanoma progression and therapeutic targets.
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