Bladder glandular cystitis causing renal dysfunction: A case report.

Area of Science:

• Urology
• Oncology
• Pathology

Background:

• Glandular cystitis (GC) is a rare bladder condition characterized by urothelial metaplasia, often associated with chronic irritation.
• It can mimic malignant bladder tumors, necessitating accurate histopathological diagnosis using markers such as CK7 and CK20.
• While typically benign, GC carries a risk of co-existing carcinoma, mandating long-term patient surveillance.

Observation:

• A 68-year-old active smoker presented with symptoms of acute kidney injury, flank pain, and urinary issues.
• Imaging revealed bilateral hydronephrosis and a significant bladder lesion.
• Histopathology confirmed intestinal glandular cystitis after transurethral resection.

Findings:

• The patient experienced symptom relief and improved quality of life following treatment and stabilization.
• Three-year surveillance cystoscopies showed no recurrence of the glandular cystitis.
• Diagnosis was confirmed using cystoscopy, histopathology, and immunohistochemical markers.

Implications:

• Glandular cystitis requires prompt recognition and diagnosis to guide appropriate management strategies.
• Vigilant follow-up is essential due to the potential for malignant transformation in some cases.
• This case highlights the importance of tailored management and ongoing care for rare bladder conditions like GC.