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Association between different triglyceride glucose index-related indicators and overactive bladder
Yuhan Huang1, Kaiyuan Wang1, Wenjing Wang1
1Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China.
Diabetes Research and Clinical Practice
|March 24, 2025
Summary
Metabolic anomalies are linked to overactive bladder (OAB). This study found triglyceride glucose (TyG) index indicators are associated with OAB, with TyG-WHtR showing the strongest predictive ability.
Area of Science:
- Metabolic health and urology
- Biostatistics and epidemiology
Background:
- Overactive bladder (OAB) is characterized by urinary urgency.
- Metabolic anomalies are implicated in OAB pathogenesis.
- Investigating triglyceride glucose (TyG) index indicators' association with OAB is crucial.
Purpose of the Study:
- To examine the relationship between various TyG index-related indicators and OAB.
- To assess the predictive power of these indicators for OAB.
Main Methods:
- Analysis of 9024 participants (aged ≥20 years) from NHANES 2005-2018.
- Weighted multivariate logistic regression, subgroup, and interaction analyses were performed.
- ROC analysis, DeLong's test, and confusion matrix evaluated predictive performance.
Main Results:
- TyG index indicators showed a positive association with OAB.
- Associations varied significantly across age and physical activity subgroups (p for interaction < 0.1).
- TyG-WHtR exhibited the highest predictive ability (AUC = 0.625) in the overall population, particularly in individuals <60 years and those with moderate-to-vigorous physical activity.
Conclusions:
- A positive association exists between TyG index indicators and OAB.
- TyG-WHtR demonstrates the strongest predictive performance for OAB in the general population.
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