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Pediatric Neuropsychiatric Syndromes: Updates on COVID-19 Infection and Vaccination
Sarah O'Dor1,2, Celia Adams1, Jessica Gavin3
1Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
COVID-19 infection can worsen PANS/PANDAS symptoms in children already experiencing them. Vaccination side effects were generally mild, with most patients not reporting worsened PANS/PANDAS symptoms post-vaccination.
Area of Science:
- Pediatric Neurology
- Infectious Diseases
- Immunology
Background:
- COVID-19 is linked to neuropsychiatric issues in children.
- Impact on pediatric acute-onset neuropsychiatric syndrome (PANS) and PANDAS is understudied.
- Understanding COVID-19's effect on PANS/PANDAS is crucial.
Purpose of the Study:
- Assess COVID-19 symptom prevalence and severity in children with PANS/PANDAS.
- Evaluate PANS/PANDAS symptom changes after COVID-19 infection or vaccination.
- Investigate vaccine hesitancy related to PANS/PANDAS exacerbation.
Main Methods:
- Retrospective analysis of caregiver-reported survey data from MGH and IPR.
- Collected data on COVID-19 history, vaccination, side effects, and PANS/PANDAS symptom changes.
- Stratified results by case and sibling groups within the IPR sample.
Main Results:
- Mild to moderate COVID-19 symptoms were common (62-75%) in infected patients.
- All PANS/PANDAS patients symptomatic during COVID-19 infection experienced symptom exacerbation.
- Fatigue was the most common vaccine side effect (30-56%); most did not report worsened PANS/PANDAS symptoms post-vaccination.
Conclusions:
- COVID-19 infection and vaccination are common in children with PANS/PANDAS.
- COVID-19 infection exacerbates PANS/PANDAS symptoms in currently symptomatic children.
- Vaccination generally did not worsen PANS/PANDAS symptoms, despite caregiver concerns.
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