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Subchronic toxicity study of sodium o-phenylphenate in mice
Abstract:
A 13-week subchronic oral toxicity study of sodium o-phenylphenate (SOPP) was conducted in B6C3F1 mice. Body weight gain was significantly depressed in 1.0 and 2.0% SOPP-treated males and in both sexes treated with 4.0%. Urinalysis showed an increase in pH and a decrease of specific gravity in the 4.0% group of both sexes. Relative liver weights of both sexes receiving 1.0, 2.0 and 4.0% SOPP were significantly greater than those of the controls. No treatment-related histopathologic findings were noted. On scanning electron microscopic (SEM) examination, the bladder epithelium of mice given 2.0% SOPP appeared normal at any time periods investigated. This study showed that while 4.0% SOPP was very toxic to both sexes, 2.0% SOPP did not cause statistically significant changes in organ weights.
Insights
High doses of sodium o-phenylphenate (SOPP) caused toxicity in mice, including reduced body weight gain and increased liver weight. Lower doses did not significantly alter organ weights, indicating dose-dependent effects.
Area of Science:
- Toxicology
- Animal Studies
- Chemical Safety
Background:
- Sodium o-phenylphenate (SOPP) is a chemical compound with various industrial applications.
- Understanding the subchronic toxicity of SOPP is crucial for assessing potential health risks.
Purpose of the Study:
- To evaluate the 13-week subchronic oral toxicity of sodium o-phenylphenate (SOPP) in B6C3F1 mice.
- To determine dose-dependent effects and identify target organs.
Main Methods:
- Oral administration of SOPP at different concentrations (1.0%, 2.0%, 4.0%) to B6C3F1 mice for 13 weeks.
- Monitoring body weight, performing urinalysis, and assessing relative organ weights.
- Histopathological examination and scanning electron microscopy (SEM) of bladder epithelium.
Main Results:
- Significant depression in body weight gain observed in males at 1.0% and 2.0% SOPP, and in both sexes at 4.0% SOPP.
- Urinalysis revealed increased pH and decreased specific gravity in the 4.0% SOPP group.
- Increased relative liver weights in both sexes across all tested SOPP concentrations (1.0%, 2.0%, 4.0%).
- No treatment-related histopathological findings or SEM abnormalities in bladder epithelium at 2.0% SOPP.
Conclusions:
- Sodium o-phenylphenate (SOPP) exhibits dose-dependent toxicity in mice, with 4.0% being highly toxic.
- While high doses affect body weight and liver, 2.0% SOPP did not induce significant organ weight changes or bladder abnormalities.