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Published on: January 7, 2019
Classic Psychedelics for the Treatment of Depression: Potential Benefits and Challenges
Sharmin Ghaznavi1,2, Sarah G Richter3
1Department of Psychiatry, Center for the Neuroscience of Psychedelics, Massachusetts General Hospital, 149 13th St, Charlestown, MA, 02129, USA. sghaznavi@mgh.harvard.edu.
Abstract:
There has been a recent resurgence in research on psychedelics as therapeutic agents for psychiatric conditions. This leading article outlines the studies to date of classic psychedelic treatments for treatment-resistant depression and major depression, including psilocybin, ayahuasca, dimethyltryptamine (DMT), and O-methyl-bufotenine (5-Me-O DMT). We discuss the potential of expanding treatment options for depression based on the data available, as well as the difficulties and limitations of research on psychedelics that make assessing that potential more challenging.
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