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Updated: May 20, 2025
06:12
Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
Published on: May 3, 2024
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Mechanistic insights into gasdermin-mediated pyroptosis
Yang Bai1, Youdong Pan2, Xing Liu3,4
1Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China.
Nature Reviews. Molecular Cell Biology
|March 25, 2025
Summary
Pyroptosis is an inflammatory cell death process involving gasdermin (GSDM) proteins. Understanding GSDM-mediated pyroptosis offers potential for new treatments for inflammatory and autoimmune diseases.
Area of Science:
- Cell Biology
- Immunology
- Molecular Biology
Background:
- Pyroptosis is a programmed inflammatory cell death pathway.
- It is executed by gasdermin (GSDM) proteins.
- Pyroptosis plays roles in immunity, host defense, and disease pathogenesis.
Purpose of the Study:
- To review current knowledge on GSDM-mediated pyroptosis.
- To discuss its initiation, execution, and regulation.
- To highlight therapeutic strategies targeting pyroptosis.
Main Methods:
- Literature review of GSDM-mediated pyroptosis.
- Analysis of pyroptosis roles in physiological and pathological processes.
- Examination of programmed cell death crosstalk.
Main Results:
- GSDM proteins mediate pyroptosis in response to cellular stress.
- Pyroptosis releases inflammatory mediators, contributing to disease.
- Targeting pyroptotic pathways shows therapeutic potential.
Conclusions:
- GSDM-mediated pyroptosis is a critical inflammatory process.
- Dysregulation of pyroptosis contributes to various diseases.
- Developing drugs targeting pyroptosis is a promising therapeutic avenue.
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