Related Experiment Video
Updated: May 20, 2025

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
Published on: May 21, 2020
Retrotransposon: an insight into neurological disorders from perspectives of neurodevelopment and aging
Wenchuan Zhang1, Chenxuan Huang1, Haiyang Yao1
1School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Abstract:
Neurological disorders present considerable challenges in diagnosis and treatment due to their complex and diverse etiology. Retrotransposons are a type of mobile genetic element that are increasingly revealed to play a role in these diseases. This review provides a detailed overview of recent developments in the study of retrotransposons in neurodevelopment, neuroaging, and neurological diseases. Retrotransposons, including long interspersed nuclear elements-1, Alu, SINE-VNTR-Alu, and endogenous retrovirus, play important regulatory roles in the development and aging of the nervous system. They have also been implicated in the pathological processes of several neurological diseases, including Alzheimer's disease, X-linked dystonia-parkinsonism, amyotrophic lateral sclerosis, autism spectrum disorder, and schizophrenia. Retrotransposons provide a new perspective for understanding the molecular mechanisms underlying neurological diseases and provide insights into diagnostic and therapeutic strategies of these diseases.
More Related Videos
08:44Generation of Topically Transgenic Rats by In utero Electroporation and In vivo Bioluminescence Screening
Published on: September 24, 2013
08:24In utero Electroporation followed by Primary Neuronal Culture for Studying Gene Function in Subset of Cortical Neurons
Published on: October 8, 2010
Related Concept Videos
Non-LTR Retrotransposons
LTR Retrotransposons
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
DNA-only Transposons
The donor site from where the transposon is excised is either degraded or...
Overview of Transposition and Recombination
Retroviruses