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Related Experiment Video

Updated: May 20, 2025

An Acupoint Catgut-embedding Therapy for Treating Obesity

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

Severe obesity with hypo-leptinemia.

Masanori Kita¹, Shuhei Morita¹, Hiroyuki Ariyasu²

¹First Department of Medicine, Wakayama Medical University, Wakayama 641-8509, Japan.

Endocrine Journal

|March 25, 2025

Summary

Hypo-leptinemia, a condition of low leptin, is linked to obesity and increased appetite. In severe obesity cases, leptin replacement therapy may be considered even without genetic abnormalities.

Keywords:

Hypopituitarism Hypothalamic disorders Leptin Obesity

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Area of Science:

Endocrinology
Metabolic Disorders
Obesity Research

Background:

Obesity is sometimes associated with hypo-leptinemia, potentially leading to increased appetite and weight gain.
Leptin replacement therapy is a theoretical treatment for hypo-leptinemia-related obesity, but requires further case studies.

Purpose of the Study:

To investigate serum leptin levels and their correlation with body mass index (BMI) in 107 obese patients.
To identify individuals with hypo-leptinemia and analyze a specific case of congenital hypopituitarism with severe obesity.

Main Methods:

Serum leptin levels and BMI were measured in 107 obese patients.
A detailed clinical and pathological investigation was conducted on one patient with congenital hypopituitarism, including genetic analysis and electron microscopy of adipose tissue.

Main Results:

One patient with congenital hypopituitarism presented with severe obesity (BMI 41.5 kg/m²), central hypogonadism, diabetes insipidus, growth hormone deficiency, cognitive impairment, and abnormal eating behavior.
Genetic analysis showed no mutations in leptin-related genes. Subcutaneous adipose tissue revealed relatively smaller adipocytes compared to a BMI-matched control.
The patient experienced progressive health issues, including dialysis and eventual death from pneumonia.

Conclusions:

Severe obesity with hypo-leptinemia may involve disturbances in adipocyte expansion due to unknown dysfunctions.
Leptin-replacement therapy could be considered for severely obese patients with hypo-leptinemia, even in the absence of identified abnormalities in leptin-related genes.