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Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Updated: May 20, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

High-Resolution Microperimetry for Detecting Glaucomatous Damage: A Prospective Evaluation of Performance.

Marc G Sarossy^1,2, Sandy Rezk¹, Dongzhe Li¹

¹Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.

Clinical & Experimental Ophthalmology

|March 25, 2025

Summary

High-resolution microperimetry demonstrates superior performance in detecting glaucoma-related visual field loss compared to standard automated perimetry. This advanced testing method, utilizing fundus-tracking and higher-resolution sampling, offers improved diagnostic potential for glaucoma.

Keywords:

glaucoma microperimetry optical coherence tomography visual field tests

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Published on: May 11, 2015

Area of Science:

Ophthalmology
Visual Neuroscience

Background:

Glaucoma diagnosis relies on detecting visual field loss.
Standard automated perimetry (SAP) is a common method for visual field testing.
Optical coherence tomography (OCT) provides structural information about the optic nerve.

Purpose of the Study:

To compare the efficacy of high-resolution microperimetry against SAP in identifying glaucomatous damage.
To evaluate the diagnostic performance of microperimetry in conjunction with OCT findings.

Main Methods:

250 eyes underwent high-resolution microperimetry and SAP using distinct stimulus patterns.
Glaucomatous damage was independently assessed by two graders using OCT scans (circumpapillary, optic disc, and widefield).
Statistical analyses, including multivariable logistic regression and receiver operating characteristic curves, were employed.

Main Results:

Both high-resolution microperimetry and SAP parameters (MTD, PSD) correlated with glaucomatous damage.
High-resolution microperimetry showed significantly better performance (pAUC=0.86) than SAP (pAUC=0.75) in prediction models (p=0.007).
Reduced resolution in microperimetry still outperformed SAP, indicating the value of higher sampling density.

Conclusions:

High-resolution microperimetry offers enhanced detection of glaucomatous visual field defects compared to SAP.
Fundus-tracking and higher-resolution sampling in microperimetry show significant potential for improving glaucoma diagnosis.