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Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes
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Targeting Immune Cell Metabolism: A Promising Therapeutic Approach for Cardiovascular Disease

Dexiang Xia1,2, Qinwen Zheng1, Yue Liu3

  • 1Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang, China.

Immunology
|March 25, 2025
PubMed

Insights

Cardiovascular disease (CVD) involves metabolic changes that impact immune responses. Targeting these metabolic and immune pathways offers new therapeutic strategies for CVD prevention and treatment.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Metabolic Research

Background:

  • Cardiovascular disease (CVD) is a major global health concern, causing significant morbidity and mortality.
  • Emerging research highlights the critical role of metabolic remodelling in CVD development and progression.
  • Metabolic alterations in the cardiovascular system are increasingly recognized for their influence on immune responses.

Purpose of the Study:

  • To review the intricate interplay between cardiovascular metabolic changes and immune responses in CVD.
  • To explore potential therapeutic interventions targeting metabolic and immune dysregulation in CVD.

Main Methods:

  • Comprehensive literature review of preclinical and clinical studies.
  • Analysis of research on metabolic pathways and immune system interactions in cardiovascular pathology.

Main Results:

  • Metabolite remodelling is a key driver in the pathology of cardiovascular disease.
  • Metabolic transformations directly contribute to CVD progression and modulate cardiovascular immune responses.
  • Understanding these interactions is crucial for developing novel therapeutic strategies.

Conclusions:

  • Targeting metabolic and immunological pathways presents a promising avenue for innovative CVD treatments.
  • Developing strategies based on metabolic and immune dysregulation can improve patient outcomes.
  • Interventions focused on these pathways may help reduce the global burden of cardiovascular disease.

Keywords:
cardiovascular diseaseimmune cellsinflammationmetabolic remodelling

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