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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

295
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
295
Non-Oral Extravascular Drug Absorption Routes01:15

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Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
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Related Experiment Video

Updated: May 20, 2025

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
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Transdermal microneedle patch for antioxidants release.

Samuel Mugo1, Scott Robertson1, Weihao Lu1

  • 1Physical Sciences Department, Macewan University, 10700-104 Avenue, Edmonton, AB T5J 4S2 Canada.

Discover Materials
|March 25, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a novel beeswax-molded microneedle patch for controlled transdermal drug delivery. The conductive polymer microneedles effectively released model drugs, showing promise for future clinical applications.

Keywords:
Antioxidant controlled releaseElectrochemotherapeutic platformsPolymer microneedle patchesTransdermal drug delivery

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Polymer-based microneedle patches offer patient-compliant transdermal drug delivery.
  • Smart and controlled microneedle systems are an emerging research area.
  • Accessible fabrication methods for microneedles are needed.

Purpose of the Study:

  • To develop an accessible method for molding microneedles using a beeswax mold.
  • To evaluate a polymer-based microneedle platform for controlled transdermal drug release.
  • To assess the drug release capabilities of conductive polydimethylsiloxane integrated with carbon nanotubes, cellulose nanocrystal, and polyaniline (PDMS@CNT/CNC@PANI) microneedles.

Main Methods:

  • Fabrication of microneedles using a beeswax mold and layer-by-layer assembly of PDMS@CNT/CNC@PANI.
  • Loading of model compounds (thymol blue and rutin) onto the microneedle patches.
  • Evaluation of transdermal drug release using chicken skin as a human skin analogue, assessing both passive and voltage-mediated diffusion.

Main Results:

  • The PDMS@CNT/CNC@PANI microneedle patch demonstrated effective drug loading, stabilization, and controlled release.
  • Both electrochemical and passive release of rutin from the microneedle patch achieved approximately 66% release.
  • The PDMS@CNC/CNT@PANI patch loaded with rutin showed a release range of 66-84%.

Conclusions:

  • The developed microneedle patches effectively release drugs in a controlled manner.
  • The accessible fabrication method using beeswax molds is viable.
  • These novel microneedle patches show significant potential for clinical transdermal drug release applications.