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Fibrinogen levels and bleeding risk in adult extracorporeal cardiopulmonary resuscitation: multicenter observational
Seiya Kanou1,2, Eiji Nakatani1,3, Tetsumei Urano1
1Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.
Abstract:
•Hypofibrinogenemia frequently occurs in extracorporeal cardiopulmonary resuscitation (ECPR) and may heighten bleeding risk. This subanalysis of a multicenter observational study (SAVE-J II) included 2,100 adult patients receiving ECPR after out-of-hospital cardiac arrest at 36 facilities in Japan.•Overall, 7.5% of patients experienced non-cannulation hemorrhagic complications, and those with fibrinogen levels below 140 mg/dL at ECPR initiation faced significantly higher bleeding risk. These findings underscore the importance of monitoring and managing fibrinogen levels in ECPR to mitigate hemorrhagic events and improve patient outcomes.
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