Extranodal T/NK-cell lymphoma with fronto-orbital localization: A case report

Area of Science:

• Pediatric oncology
• Neuro-oncology
• Ophthalmology

Background:

• Orbito-cerebral lymphoma is a rare extranodal non-Hodgkin lymphoma predominantly affecting children.
• The condition impacts both the orbital and cerebral regions, presenting diagnostic challenges due to its mimicry of other diseases.

Observation:

• Symptoms are diverse, encompassing ocular, neurological, and systemic manifestations, often leading to delayed diagnosis.
• Magnetic Resonance Imaging (MRI) is the cornerstone for accurate diagnosis of pediatric orbito-cerebral lymphoma.

Findings:

• Treatment strategies combine chemotherapy, radiotherapy, and emerging targeted therapies, significantly enhancing patient survival rates.
• Prognosis is generally favorable for localized disease, whereas advanced stages or central nervous system involvement correlate with increased recurrence risk.

Implications:

• Improved diagnostic protocols and multimodal treatment approaches are crucial for managing this rare pediatric cancer.
• Long-term surveillance is essential for detecting recurrence and managing potential long-term side effects of treatment in survivors.