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SARS-CoV-2 Infection, Vaccination, and Irritable Bowel Syndrome in Veterans: A Cross-Sectional Study
Arash Oliver Parsi1, George Nicholas Verne2,3, Yu Jiang4
1Metairie Park Country Day School, Metairie, USA.
COVID-19 infection significantly increases the risk of developing irritable bowel syndrome (IBS). Vaccination against COVID-19 reduces this risk, offering protection against both infection and subsequent IBS development.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Public Health
Background:
- The relationship between SARS-CoV-2 (COVID-19) infection and irritable bowel syndrome (IBS) requires further investigation.
- Understanding this association is crucial for managing post-infection sequelae.
Purpose of the Study:
- To determine a potential mechanistic link between COVID-19 infection and IBS.
- To evaluate the role of COVID-19 vaccination in this relationship.
Main Methods:
- A cross-sectional study analyzed 9,112 veterans from the Veterans Affairs electronic healthcare database.
- Data included demographics, COVID-19 infection history, vaccination status, and IBS diagnosis.
- Univariate and multivariate logistic regression models were employed.
Main Results:
- COVID-19 infection was significantly associated with an increased odds of IBS (OR=1.94).
- COVID-19 vaccination was significantly associated with a reduced odds of IBS (OR=1.49).
- Vaccinated individuals without COVID-19 infection had a lower IBS risk than unvaccinated individuals with COVID-19.
Conclusions:
- COVID-19 infection nearly doubles the likelihood of developing IBS.
- COVID-19 vaccination mitigates IBS risk by reducing infection likelihood.
- Vaccination strategies can diminish the overall risk of IBS development in the veteran population.
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