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The use of cannabinoid therapy in treatment-refractory isolated REM sleep behavior disorder: a case report
Sahej Samra1,2, Hrayr Attarian2, Roneil Malkani2,3
1University of Southern California, Los Angeles, California.
Abstract:
Current treatments for rapid eye movement sleep behavior disorder are not always effective and can lead to dose-limited adverse events, and new treatments are needed for this condition. We present a case of a patient with treatment-refractory isolated rapid eye movement sleep behavior disorder who had a dramatic and sustained improvement in dream enactment behaviors using oral tinctures containing cannabidiol and tetrahydrocannabinol without adverse events over 5 years of follow-up.
Citation:
Samra S, Attarian H, Malkani R. The use of cannabinoid therapy in treatment-refractory isolated REM sleep behavior disorder: a case report. J Clin Sleep Med. 2025;21(7):1311-1313.
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