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Serum hepatitis B core antibody as the prognostic factor for diffuse large B-cell lymphoma
Yi Rong1,2, Ming Wang1, Yaqiong Ma1
1Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China.
Microbiology Spectrum
|March 25, 2025
Summary
Hepatitis B core antibody (HBcAb) is a significant prognostic indicator for hepatitis B virus (HBV)-associated diffuse large B-cell lymphoma (DLBCL). Positive HBcAb correlates with reduced survival and lower CD23 expression, suggesting combined use for risk assessment.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL).
- Hepatitis B virus (HBV) infection is linked to DLBCL, but specific prognostic markers are lacking.
- Current clinical markers for HBV-associated DLBCL are insufficient for accurate prognosis.
Purpose of the Study:
- To identify prognostic indicators for HBV-associated DLBCL.
- To analyze the relationship between tissue markers, HBV serum markers, and clinical outcomes in DLBCL patients.
- To evaluate the prognostic value of hepatitis B core antibody (HBcAb) and CD23 expression.
Main Methods:
- Retrospective analysis of DLBCL patient data.
- Assessment of HBV serum markers, including HBcAb.
- Evaluation of CD23 molecule expression in DLBCL tissue samples.
- Correlation analysis between HBcAb status, CD23 expression, and overall survival (OS).
Main Results:
- DLBCL patients positive for HBcAb showed significantly reduced overall survival (OS) rates.
- Elevated HBcAb positivity correlated with reduced CD23 expression in DLBCL tissue.
- Combined HBcAb and CD23 status demonstrated significant disparities in OS rates, indicating prognostic value.
Conclusions:
- Hepatitis B core antibody (HBcAb) is a significant prognostic indicator for HBV-associated DLBCL.
- The combination of HBcAb and CD23 expression can improve prognostic assessments for HBV-associated DLBCL.
- These findings offer novel indicators and diagnostic strategies for risk stratification and treatment planning in HBV-associated DLBCL.
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