Related Experiment Video

Updated: Apr 30, 2026

Efficient Recombinant Parvovirus Production with the Help of Adenovirus-derived Systems
13:47

Efficient Recombinant Parvovirus Production with the Help of Adenovirus-derived Systems

Published on: April 23, 2012

10.3K

Parechovirus: neglected for too long?

Fahmida Alam1, You Li2, Matthew R Vogt1,2

  • 1Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Journal of Virology
|March 25, 2025
PubMed

Insights

Parechoviruses infect many species, causing mild illness in children but severe neurological disease in infants. This review examines human and nonhuman parechovirus characteristics to understand their impact.

Area of Science:

  • Virology
  • Infectious Diseases
  • Molecular Biology

Background:

  • Parechoviruses are RNA viruses found in various vertebrates.
  • Human infections are common, causing mild symptoms, but can lead to severe neurological illness in infants.
  • Rodent parechoviruses are associated with serious conditions like encephalitis and perinatal death.

Purpose of the Study:

  • To review the isolation history of human and nonhuman parechoviruses.
  • To analyze global distribution, seroprevalence, and evolutionary aspects.
  • To explore factors influencing host specificity, virulence, and pathogenesis.

Main Methods:

  • Literature review of parechovirus isolation and characteristics.
  • Analysis of existing data on global distribution and seroprevalence.
  • Synthesis of information on viral biology and evolution.

Main Results:

  • Parechoviruses have a broad host range across vertebrate species.
  • Significant variations exist in clinical manifestations and disease severity.
  • Understanding viral biology and evolution is crucial for explaining host-specific impacts.

Conclusions:

  • Further research is needed to fully characterize nonhuman parechoviruses.
  • Factors like viral evolution and host immunity likely shape disease dynamics.
  • This review provides a foundation for future studies on parechovirus pathogenesis and control.
Keywords:
parechoviruspicornavirus

More Related Videos

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat08:27

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Published on: October 29, 2014

13.1K
A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

9.4K

Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
1.5K
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
1.2K
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
88
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
196
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
101
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
23