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Corrigendum for the article Clin Nephrol. 2025; 103: 1-4

Fredrik Barth Brekke, Nanna von der Lippe, Ine Røed

    Clinical Nephrology
    |March 25, 2025
    PubMed

    Insights

    Hyperbaric oxygen therapy shows no survival difference for calciphylaxis patients on renal replacement therapy. This study corrects patient classification for chronic kidney disease stage 5 (CKD5) to ensure accurate results.

    Area of Science:

    • Nephrology
    • Dermatology
    • Hyperbaric Medicine

    Background:

    • Calciphylaxis is a severe condition with high mortality.
    • Multidisciplinary care is standard for calciphylaxis.
    • Hyperbaric oxygen therapy (HBOT) is an adjunctive treatment under investigation.

    Purpose of the Study:

    • To evaluate the efficacy of HBOT in calciphylaxis patients.
    • To assess survival rates in patients with calciphylaxis receiving HBOT.
    • To correct data errors in a previously published study.

    Main Methods:

    • Retrospective analysis of patients with calciphylaxis treated with HBOT and conventional care.
    • Correction of patient data regarding chronic kidney disease stage 5 (CKD5) and renal replacement therapy (RRT).
    • Survival analysis comparing patients on RRT versus those not on RRT.

    Main Results:

    • A correction was made to the number of CKD5 patients on RRT at diagnosis (15 patients, 60%) compared to the initial report (10 patients, 40%).
    • Despite data correction, survival analysis confirmed no significant difference in survival between patients on RRT and those not on RRT.
    • The overall results and conclusions of the study remain valid after recalculating statistics.

    Conclusions:

    • Hyperbaric oxygen therapy as an adjunct to multidisciplinary care does not alter survival outcomes in calciphylaxis patients.
    • Accurate patient classification, particularly regarding CKD5 and RRT status, is crucial for study integrity.
    • The study reaffirms the importance of comprehensive care for calciphylaxis, with HBOT not demonstrating a survival benefit in this cohort.

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