Related Experiment Video
Updated: May 5, 2026
08:21
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
4.9K
Corrigendum for the article Clin Nephrol. 2025; 103: 1-4
Clinical Nephrology
|March 25, 2025
Summary
Hyperbaric oxygen therapy shows no survival difference for calciphylaxis patients on renal replacement therapy. This study corrects patient classification for chronic kidney disease stage 5 (CKD5) to ensure accurate results.
Area of Science:
- Nephrology
- Dermatology
- Hyperbaric Medicine
Background:
- Calciphylaxis is a severe condition with high mortality.
- Multidisciplinary care is standard for calciphylaxis.
- Hyperbaric oxygen therapy (HBOT) is an adjunctive treatment under investigation.
Purpose of the Study:
- To evaluate the efficacy of HBOT in calciphylaxis patients.
- To assess survival rates in patients with calciphylaxis receiving HBOT.
- To correct data errors in a previously published study.
Main Methods:
- Retrospective analysis of patients with calciphylaxis treated with HBOT and conventional care.
- Correction of patient data regarding chronic kidney disease stage 5 (CKD5) and renal replacement therapy (RRT).
- Survival analysis comparing patients on RRT versus those not on RRT.
Main Results:
- A correction was made to the number of CKD5 patients on RRT at diagnosis (15 patients, 60%) compared to the initial report (10 patients, 40%).
- Despite data correction, survival analysis confirmed no significant difference in survival between patients on RRT and those not on RRT.
- The overall results and conclusions of the study remain valid after recalculating statistics.
Conclusions:
- Hyperbaric oxygen therapy as an adjunct to multidisciplinary care does not alter survival outcomes in calciphylaxis patients.
- Accurate patient classification, particularly regarding CKD5 and RRT status, is crucial for study integrity.
- The study reaffirms the importance of comprehensive care for calciphylaxis, with HBOT not demonstrating a survival benefit in this cohort.
Related Concept Videos
01:06Renal Drug Clearance: Overview
1.1K
Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
1.1K
01:25Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant
371
In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
371
01:22Acute Kidney Injury I: Introduction
1.4K
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
1.4K
01:29Acute Kidney Injury II: Pathophysiology
2.3K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
2.3K
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
559
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
559
01:24Chronic Kidney Disease II: Clinical Manifestations
1.1K
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K