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Updated: May 20, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Neuroinflammation-mediated relationship between oral microbiome and neurodegenerative diseases
Ziyan Kong1, Shunjiayi Hu2, Xiaoyue Lei1
1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.
Abstract:
Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS), affect millions of people worldwide. While considerable progress has been made to elucidate the pathogenesis of these diseases in recent years, their specific mechanisms remain largely unknown. Many research study results have proven a certain association between the oral microbiome and neurodegenerative diseases. This review focuses on the relationship between the oral microbiome and neurodegenerative diseases, with a particular focus on the mechanisms of neuroinflammation.
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