The potential of Abrus precatorius leaves in arthritis alleviation computational approaches through lC-MS analysis
Sukanya Vijayan1, Thirumal Margesan
1Department of Pharmacognosy, SRM College of Pharmacy, SRMIST, Chengalpattu, Tamil Nadu, India.
Aim:
This study explores the therapeutic potential of Abrus precatorius leaves in arthritis treatment using computational methods and LC-MS analysis.
Methods:
The plant material was taxonomically authenticated, and phytochemical analysis identified bioactive compounds such as alkaloids, flavonoids, and triterpenoids.
Results:
Swiss ADME analysis confirmed that multiple compounds complied with Lipinski's Rule of Five, while OSIRIS software indicated minimal toxicity. PASS analysis predicted anti-inflammatory and antioxidant activities. Molecular docking simulations of Abrine with key rheumatoid arthritis (RA) targets revealed strong binding affinities, suggesting potential mechanisms for RA treatment.
Conclusion:
This research highlights the medicinal potential of Abrus precatorius leaves and emphasizes the importance of computational tools in understanding their pharmacological properties for arthritis management.
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