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Diagnostic Challenges in Fuchs' Uveitis Syndrome in China: A Multi-Center Comparative Study of Three Criteria
Jianguo Huang1, Cheng Jin1, Dan Lin1
1National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Objective:
To evaluate and compare the diagnostic accuradcy of three Fuchs' Uveitis Syndrome (FUS) diagnostic criteria-La Hey Diagnostic Criteria (LHDC), the Standardization of Uveitis Nomenclature (SUN) Criteria, and Yang's Revised Diagnostic Criteria (RDC)-in the absence of a universally accepted gold standard.
Methods:
A multicenter, case-control study was conducted with 673 patients (331 FUS and 342 non-FUS) from three tertiary eye centers in China. Sensitivity, specificity, and area under the curve (AUC) values were calculated and compared across the three criteria.
Results:
RDC demonstrated the highest sensitivity (86.1%), followed by LHDC (61.9%) and SUN (54.4%). The SUN criteria had the highest specificity (98.5%), with no statistically significant differences in specificity between the criteria. RDC showed superior diagnostic performance with an AUC of 0.909. Key diagnostic features contributing to the higher sensitivity of RDC included the absence of posterior synechiae, stellate keratic precipitates, and diffuse iris depigmentation.
Conclusion:
The RDC provides enhanced sensitivity for diagnosing FUS within Chinese populations, suggesting that tailoring diagnostic criteria to demographic characteristics may improve diagnostic precision and clinical application.
