Advances in classification and treatment of primary cutaneous lymphomas

Primary cutaneous lymphomas (PCLs) are a heterogeneous group of extranodal non-Hodgkin lymphomas, characterized with skin involvement as the primary or predominant manifestation. While early-stage PCLs typically have a favorable prognosis, managing patients with aggressive progression or advaced stages remains a challenge. Recent advancements in molecular biology and sophisticated clinical laboratory tests have significantly improved the classification and management of PCLs, which provide more targeted and effective treatment strategies for patients. This review summarizes the latest classification schemes and therapeutic options for PCLs, with a focus on the latest developments and future directions in the field.