Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Equilibrium and Balance01:15

Equilibrium and Balance

4.3K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
4.3K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

399
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
399
The Vestibular System01:29

The Vestibular System

39.2K
The vestibular system is a set of inner ear structures that provide a sense of balance and spatial orientation. This system is comprised of structures within the labyrinth of the inner ear, including the cochlea and two otolith organs—the utricle and saccule. The labyrinth also contains three semicircular canals—superior, posterior, and horizontal—that are oriented on different planes.
39.2K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

137
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
137
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

399
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
399
Dementia01:30

Dementia

78
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
78

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Epidemiology and Clinical Presentation of the Acute Imbalance Syndrome (AIS)-A Systematic Review and Meta-Analysis.

European journal of neurology·2026
Same author

Prevalence and direct costs of vestibular disease in France - matched case-control study results from the 2022 and 2023 french health data system.

Cost effectiveness and resource allocation : C/E·2026
Same author

Confirmatory factor analysis and Rasch analysis of the German revised version of the Niigata PPPD questionnaire: NPQ-R.

Frontiers in neurology·2026
Same author

Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers.

Alzheimer's research & therapy·2026
Same author

Detection of Focal Lesions in Epilepsy with [<sup>18</sup>F]UCB-H Synaptic Vesicle Protein 2A PET Imaging.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Superior oblique myokymia: diagnostic criteria and long-term outcome.

Journal of neurology·2026

Related Experiment Video

Updated: May 20, 2025

Behavioral Assessment of the Aging Mouse Vestibular System
09:30

Behavioral Assessment of the Aging Mouse Vestibular System

Published on: July 11, 2014

16.8K

Vestibular dysfunction: a hidden risk factor for Alzheimer's disease.

Carolin Anna Maria Koriath1, Boris Rauchmann2, Florian Schoeberl3

  • 1Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany. carolin.koriath@med.uni-muenchen.de.

Journal of Neurology
|March 25, 2025
PubMed
Summary

Peripheral vestibular dysfunction (PVD) significantly increases Alzheimer's disease (AD) risk by 1.7 times, even after accounting for lifestyle factors. Maintaining vestibular function may be crucial for brain health and preventing AD.

Keywords:
AgingAlzheimer’s diseaseDementiaNeurodegenerationSensory systemsVertigo

More Related Videos

Using Unidirectional Rotations to Improve Vestibular System Asymmetry in Patients with Vestibular Dysfunction
05:02

Using Unidirectional Rotations to Improve Vestibular System Asymmetry in Patients with Vestibular Dysfunction

Published on: August 30, 2019

7.1K
Estimating Vestibular Perceptual Thresholds Using a Six-Degree-Of-Freedom Motion Platform
06:31

Estimating Vestibular Perceptual Thresholds Using a Six-Degree-Of-Freedom Motion Platform

Published on: August 4, 2022

2.9K

Related Experiment Videos

Last Updated: May 20, 2025

Behavioral Assessment of the Aging Mouse Vestibular System
09:30

Behavioral Assessment of the Aging Mouse Vestibular System

Published on: July 11, 2014

16.8K
Using Unidirectional Rotations to Improve Vestibular System Asymmetry in Patients with Vestibular Dysfunction
05:02

Using Unidirectional Rotations to Improve Vestibular System Asymmetry in Patients with Vestibular Dysfunction

Published on: August 30, 2019

7.1K
Estimating Vestibular Perceptual Thresholds Using a Six-Degree-Of-Freedom Motion Platform
06:31

Estimating Vestibular Perceptual Thresholds Using a Six-Degree-Of-Freedom Motion Platform

Published on: August 4, 2022

2.9K

Area of Science:

  • Neuroscience
  • Gerontology
  • Public Health

Background:

  • Enlarged hippocampi in London taxi drivers suggest neuroprotection from navigation. Reduced Alzheimer's disease (AD) mortality in drivers implies a link between hippocampal engagement and AD risk.
  • Vestibular function is associated with hippocampal size, indicating a potential role for vestibular input in modulating AD risk.

Purpose of the Study:

  • To investigate the influence of peripheral vestibular dysfunction (PVD) on the likelihood of an Alzheimer's disease (AD) diagnosis.
  • To assess the association between PVD and AD risk, considering 16 modifiable lifestyle factors.

Main Methods:

  • Analysis of UK Biobank (UKB) volunteers aged over 55 without dementia at baseline.
  • Inclusion of 16 known modifiable lifestyle factors as covariates in the analysis.
  • Identification of Alzheimer's disease (AD) and peripheral vestibular dysfunction (PVD) cases using ICD diagnoses.

Main Results:

  • 4684 cases of Alzheimer's disease (AD) and 2133 cases of peripheral vestibular dysfunction (PVD) were identified.
  • Peripheral vestibular dysfunction (PVD) was found to increase the risk of Alzheimer's disease (AD) by 1.7 times.
  • This increased risk associated with PVD remained significant even after accounting for other known risk factors.

Conclusions:

  • Vestibular loss is linked to hippocampal atrophy and default mode network disruption, suggesting it elevates Alzheimer's disease (AD) risk.
  • Active vestibular stimulation, through methods like balance training or neuromodulation, may offer a potential strategy for modifying AD progression.
  • Targeting vestibular function could represent a novel approach in Alzheimer's disease (AD) prevention and management.