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Related Concept Videos

Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Hybridoma Technology01:31

Hybridoma Technology

Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...
Antibody Structure and Classes01:25

Antibody Structure and Classes

Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
Antibody Actions01:26

Antibody Actions

Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...

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Flow-pattern Guided Fabrication of High-density Barcode Antibody Microarray
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"All-in-One Functionalization and Synergic Ordering" Strategy Enables Multimode Anti-Counterfeiting Patterns.

Kexin Liang1, Weisheng Feng1, Yiyang Liu1

  • 1Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine, Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, 200237 Shanghai, China.

ACS Applied Materials & Interfaces
|March 25, 2025
PubMed
Summary

Researchers developed a simple strategy for creating advanced anticounterfeiting films. This method uses a photoresponsive copolymer to produce quadruple-mode patterns, overcoming limitations of traditional systems.

Keywords:
alternating copolymeranticounterfeitingordered patternsself-assemblywrinkles

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Optics

Background:

  • Conventional anticounterfeiting systems are often expensive and complex.
  • Existing methods face challenges with optical channel interference.
  • There is a need for simpler, multi-modal anti-duplication technologies.

Purpose of the Study:

  • To develop a simple and effective strategy for creating multi-mode anticounterfeiting patterns.
  • To utilize a photoresponsive alternating copolymer for advanced anti-duplication features.
  • To overcome the limitations of conventional anticounterfeiting systems.

Main Methods:

  • Fabrication of a photoresponsive alternating copolymer film, P(DPA-alt-BP).
  • Utilizing 9,10-diphenylanthracene (DPA) for photoresponse and fluorescence, and biphenyl (BP) for liquid crystal alignment and microphase separation.
  • Employing UV irradiation through a photomask followed by solvent annealing to induce gradient cross-linking and synergic ordering.

Main Results:

  • Successfully created quadruple-mode anticounterfeiting patterns on the P(DPA-alt-BP) film.
  • Demonstrated features including wrinkled patterns, substructures, distinct fluorescence, and polarized visual effects.
  • Achieved a synergic ordering effect through controlled cross-linking and microphase separation.

Conclusions:

  • The 'all-in-one functionalization and synergic ordering' strategy offers a simple yet powerful approach to anticounterfeiting.
  • The developed photoresponsive copolymer film exhibits multiple anticounterfeiting modes.
  • This method shows significant promise for high-level anticounterfeiting applications and inspires new photoresponsive material development.