Cortico-Ocular Coupling Analysis for Developmental and Behavioral Disorders: A Review.

Area of Science:

• Neuroscience
• Developmental Psychology
• Biomedical Engineering

Background:

• Developmental and behavioral disorders (DBD) significantly impact children's neurological and behavioral development.
• Current neurophysiological assessment tools for DBD exhibit considerable heterogeneity, necessitating innovative diagnostic approaches.
• Cortico-ocular coupling (COC) analysis, measuring brain-eye neural interaction, emerges as a promising alternative.

Purpose of the Study:

• To review the application of Cortico-ocular coupling (COC) analysis in the assessment of developmental and behavioral disorders (DBD).
• To explore neural substrates, research paradigms, analysis methods, and applications of COC in DBD.
• To provide insights into the validity and advancement of COC analysis for DBD diagnosis and mechanism disclosure.

Main Methods:

• Comprehensive review of existing literature on COC analysis in relation to DBD.
• Categorization of neural substrates and evocation paradigms based on functional domains (social, attention, cognition, visual, motor).
• Summary of electroencephalography (EEG) and eye-tracking features, analysis techniques, and validation datasets for COC analysis.

Main Results:

• COC analysis demonstrates validity and advancement in assessing DBD across various functional domains.
• The review outlines key neural substrates, experimental paradigms, and analytical methods crucial for implementing COC analysis.
• Applications of COC analysis in DBD reveal its potential for improved diagnostic accuracy and mechanistic understanding.

Conclusions:

• Cortico-ocular coupling (COC) analysis presents a robust and advanced method for evaluating developmental and behavioral disorders (DBD).
• Further research into limitations, challenges, and future directions is essential for optimizing COC analysis in clinical practice.
• COC analysis holds significant promise for enhancing early diagnosis and treatment strategies for children with DBD.