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Updated: May 20, 2025

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages
Published on: May 30, 2019
Dissecting transmission to understand parasite evolution
Luís M Silva1,2, Kayla C King2,3,4, Jacob C Koella1
1Institute of Biology, University of Neuchâtel, Neuchâtel, Switzerland.
Abstract:
Parasite transmission is a complex, multi-stage process that significantly impacts host-parasite dynamics. Transmission plays a key role in epidemiology and virulence evolution, where it is expected to trade off with virulence. However, the extent to which classical models on virulence-transmission relationships apply in the real world is unclear. This insight piece proposes a novel framework that breaks transmission into three distinct stages: within-host infectiousness, an intermediate between-host stage (biotic or abiotic), and new host infection. Each stage is influenced by intrinsic and extrinsic factors to the parasite, which together will determine its transmission success. Analyzing the transmission stages separately and how they affect each other might enhance our understanding of which host-, parasite- or environmental-driven factors might shape parasite evolution and inform us about new effectors to act on when designing disease control strategies.
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