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Synthesis, Characterization, and Functionalization of Hybrid Au/CdS and Au/ZnS Core/Shell Nanoparticles
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A Targeted Core-Shell ZIF-8/Au@Fe3O4 Platform with Multiple Antibacterial Pathways for Infected Skin Wound
Jing Zhang1, Yang Xue1,2, Lan Zhang1
1State-Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.
ACS Applied Materials & Interfaces
|March 25, 2025
Summary
This study introduces FZAM, a novel core-shell nanoparticle platform that effectively eliminates bacteria and promotes skin wound healing. FZAM utilizes near-infrared light to activate antimicrobial properties, accelerating tissue regeneration.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Wound Healing Research
Background:
- Bacterial infections significantly impede skin wound healing.
- Developing efficient antimicrobial strategies is crucial for effective wound regeneration.
- Novel therapeutic platforms are needed to combat infection and enhance healing.
Purpose of the Study:
- To design and evaluate a core-shell structured therapeutic platform (FZAM) for enhanced antibacterial efficiency and skin regeneration.
- To investigate the multi-pathway antimicrobial mechanisms of FZAM under near-infrared (NIR) irradiation.
- To assess the efficacy of FZAM in infected skin wound models.
Main Methods:
- Fabrication of FZAM nanoparticles with a Fe3O4 core and a ZIF-8 shell loaded with gold nanoparticles (Au NPs) and maltodextrin.
- Characterization of the Fe3O4-Au NP heterojunction for hyperthermia and reactive oxide species (ROS) generation under NIR irradiation.
- Evaluation of antibacterial activity against bacteria and assessment of cytocompatibility with fibroblasts and endothelial cells.
- In vivo testing in infected skin wound models to evaluate sterilization, anti-inflammatory effects, and skin regeneration acceleration.
Main Results:
- FZAM demonstrated significant antibacterial activity, eliminating over 99% of bacteria at 200 μg mL-1 via synergistic action of NIR-induced hyperthermia, ROS, and Zn2+ release.
- The Fe3O4-Au NP heterojunction exhibited hyperthermia, ROS generation, and peroxidase-like activity under NIR irradiation.
- FZAM showed excellent cytocompatibility and promoted fibroblast and endothelial cell biofunctions.
- In vivo studies showed FZAM effectively sterilized infected wounds, reduced inflammation, and accelerated skin regeneration.
Conclusions:
- FZAM serves as a versatile core-shell therapeutic platform for combating bacterial infections in skin wounds.
- The combination of NIR-triggered hyperthermia, ROS generation, and targeted delivery enhances antimicrobial efficacy.
- FZAM promotes skin regeneration and reduces inflammation, offering a promising strategy for infected wound management.
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