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Related Experiment Video

Updated: Jun 14, 2025

Laboratory-Engineered Glioblastoma Organoid Culture and Drug Screening

Laboratory-Engineered Glioblastoma Organoid Culture and Drug Screening

Published on: January 10, 2025

Bioengineering tools for next-generation neural organoids.

Richard O'Laughlin¹, Fangyi Cheng², Hongjun Song³

¹Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Current Opinion in Neurobiology

|March 25, 2025

Summary

This summary is machine-generated.

Bioengineering advances are enhancing human stem cell-derived neural organoids for studying brain development and disorders. These improved models overcome limitations in control and long-term analysis, paving the way for next-generation organoids.

Keywords:

3D printing bioengineering brain flexible electrode microfabrication neurodevelopment organoid

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Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

Area of Science:

Neuroscience
Developmental Biology
Bioengineering

Background:

Human stem cell-derived neural organoids mimic fetal human nervous system development.
Organoids offer insights into neurodevelopment and neurological disorders.
Current neural organoids face limitations in controlled development, spatial orientation, and long-term monitoring.

Purpose of the Study:

To review bioengineering methods for improving neural organoid formation and analysis.
To discuss how microfabrication, biomaterials, 3D printing, and flexible electrodes address organoid limitations.

Main Methods:

Review of bioengineering techniques applied to neural organoids.
Integration of microfabrication for controlled development.
Application of biomaterials and 3D printing for structural support and organization.
Use of flexible electrodes for long-term electrical activity monitoring.

Main Results:

Bioengineering strategies enhance control over neural organoid development.
Improved methods allow for better spatial orientation and structural integrity.
New technologies enable long-term morphological and electrical activity measurements.
These advancements address critical limitations of standard neural organoid models.

Conclusions:

Bioengineered neural organoids represent a significant advancement over standard models.
Future applications of next-generation neural organoids are promising for research.
These improved models will accelerate understanding of human neurodevelopment and disease.