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Evolving insights into pancreatic tumor initiation and progression through DCLK1-expressing tuft cells
Landon L Moore1, Courtney W Houchen2
1Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.
Developmental Cell
|March 25, 2025
Abstract:
In this issue of Developmental Cell, Salas-Escabillas et al. find that tuft cells undergo a tuft-to-neuroendocrine transition, switching from tumor suppressors to tumor promoters via c-Myc in pancreatic ductal adenocarcinoma (PDAC). This result offers exciting insights into PDAC's aggressiveness, therapy resistance, and high mortality.

