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Intercellular adhesion and its role in epidermal differentiation.

¹Department of Dermatology, University of Glasgow, Scotland.

Investigative & Cell Pathology

|January 1, 1978

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Epidermal keratinocyte differentiation involves changing cell adhesion, with desmosome formation early on and non-junctional interactions later. This study explores the molecular basis of these adhesive changes during skin cell development.

Area of Science:

Dermatology
Cell Biology
Biochemistry

Background:

Epidermal keratinocyte differentiation involves dynamic changes in cell-cell adhesion.
Understanding these adhesive changes is crucial for skin biology and disease.

Purpose of the Study:

To elucidate the sequence of adhesive interactions during epidermal keratinocyte differentiation.
To propose molecular mechanisms underlying desmosome formation and stability.
To investigate the role of the cytoskeleton in keratinocyte adhesion.

Main Methods:

Comparative analysis of intercellular adhesion studies in various tissue types.
Construction of molecular event sequences for desmosome formation.
Consideration of cytoskeletal involvement in cell adhesion and morphology changes.

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Main Results:

Early differentiation is characterized by predominant desmosome formation.
Later differentiation involves increased non-junctional membrane adhesion and cell flattening.
Cytoskeletal involvement is considered integral to these adhesive processes.

Conclusions:

The study outlines a model for keratinocyte differentiation based on changing adhesive properties.
Identifies key molecular events in desmosome formation and junctional stability.
Suggests avenues for future research into normal and pathological epidermal adhesion.