Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

4.9K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
4.9K
Cross-bridge Cycle01:26

Cross-bridge Cycle

116.4K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
116.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

VRK1-Related Motor Neuropathy With Upper Motor Neuron Signs and Selective Muscle Involvement.

Journal of the peripheral nervous system : JPNS·2026
Same author

Altered EEG in Creutzfeldt-Jakob Disease: Improving Diagnostic Accuracy Using American Clinical Neurophysiology Society 2021 Criteria.

Neurology. Clinical practice·2026
Same author

InnerEye-HS: a disease-agnostic clinical tool for hippocampal segmentation.

Brain communications·2026
Same author

Precision of automatically generated generic regions of interest for direct assessment of perfusion-MRI.

Frontiers in physiology·2026
Same author

Real-Time, Inline Quantitative MRI Enabled by Scanner-Integrated Machine Learning: A Proof of Principle With NODDI.

Magnetic resonance in medicine·2026
Same author

<i>C9orf72</i> poly(glycine-alanine) knock-in mice exhibit mild rotarod and proteomic changes consistent with amyotrophic lateral sclerosis/frontotemporal dementia.

Brain communications·2026

Related Experiment Video

Updated: May 20, 2025

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

19.3K

Muscle MRI quantifies disease progression in amyotrophic lateral sclerosis.

Uros Klickovic1,2, Luca Zampedri1, Nick Zafeiropoulos1,3

  • 1MND Centre, UCL Queen Square Institute of Neurology, London, UK.

Journal of Neurology, Neurosurgery, and Psychiatry
|March 25, 2025
PubMed
Summary

Skeletal muscle MRI shows promise as a reliable biomarker for tracking amyotrophic lateral sclerosis (ALS) progression. This imaging technique can detect muscle atrophy and correlate with functional decline, aiding future clinical trials.

Keywords:
ALSMRIMUSCLE DISEASENEUROMUSCULAR

More Related Videos

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

10.3K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.2K

Related Experiment Videos

Last Updated: May 20, 2025

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

19.3K
Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

10.3K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.2K

Area of Science:

  • Neuroimaging
  • Biomarkers
  • Neurology

Background:

  • Amyotrophic lateral sclerosis (ALS) requires objective biomarkers for disease progression.
  • Current outcome measures in ALS research have limitations.

Purpose of the Study:

  • To evaluate skeletal muscle magnetic resonance imaging (MRI) as a sensitive and operator-independent biomarker for ALS.
  • To assess the utility of muscle MRI in future ALS clinical trials.

Main Methods:

  • A longitudinal cohort study involving 20 ALS patients and 16 healthy controls.
  • Muscle MRI of head, neck, upper, and lower limbs was performed over 1 year.
  • Quantitative MRI parameters (CSA, VOL, fat fraction, T2m) were correlated with clinical and functional assessments.

Main Results:

  • Progressive muscle atrophy was observed in ALS patients at hand, head-neck, and lower limb regions.
  • MRI-detected muscle atrophy correlated significantly with leg muscle strength, hand grip strength, and functional rating scales.
  • Changes in cross-sectional area (CSA) and volume (VOL) were key indicators.

Conclusions:

  • Skeletal muscle MRI is an effective and sensitive neuroimaging biomarker for ALS progression.
  • Muscle MRI has significant potential as an outcome measure in ALS clinical trials.
  • This non-invasive technique offers a reliable method for monitoring disease advancement.