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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Crohn's disease
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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Updated: May 22, 2025

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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Colonic malakoplakia.

Abdulmalik Saleem1, Murtaza Hussain2, Shula Schechter3

  • 1Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan, USA.

BMJ Case Reports
|March 25, 2025
PubMed
Summary
This summary is machine-generated.

Colonic malakoplakia, a rare inflammatory condition, can present asymptomatically. Early diagnosis and treatment are crucial due to potential complications, even in healthy individuals.

Keywords:
EndoscopyGastroenterology

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Area of Science:

  • Gastroenterology
  • Pathology
  • Inflammatory Diseases

Background:

  • Colonic malakoplakia is a rare granulomatous inflammatory condition.
  • It can manifest with symptoms like abdominal pain, diarrhea, and rectal bleeding.
  • Association with colon adenocarcinoma and potential causes like chronic bacterial infections with defective macrophage lysosomal activity are noted.

Purpose of the Study:

  • To report a case of asymptomatic colonic malakoplakia found during colorectal cancer screening.
  • To highlight the importance of diagnostic and therapeutic evaluation for this rare condition.

Main Methods:

  • Case report presentation.
  • Review of limited existing literature on colonic malakoplakia.

Main Results:

  • An asymptomatic case of colonic malakoplakia was identified in a healthy woman during a screening colonoscopy.
  • The literature review indicates a scarcity of reported cases and treatment guidelines.

Conclusions:

  • Colonic malakoplakia can be asymptomatic, emphasizing the need for vigilance.
  • Thorough diagnostic and therapeutic evaluation is essential for colonic malakoplakia, regardless of symptoms, due to potential morbidity and mortality.