Decoding arthropod vector immunology through bona fide pathogens

The interrelationship between the microbiota, metabolism, and the arthropod immune system has evolved to maintain physiological equilibrium. Arthropods rely on this delicate balance when encountering fitness challenges. The understanding of life history traits in arthropod vectors has been hampered by technological difficulties compounded by limited scientific knowledge compared to established model organisms. Here, we posit that using emerging technologies to study environmental pathogens that cause greater fitness disadvantages to disease vectors (i.e., bona fide pathogens) in contrast to coevolved microbes will enable meaningful insights into arthropod immunophysiology. We propose a conceptual framework whereby understanding immunophysiology through the lens of bona fide pathogens, as opposed to coevolved microbes, should be useful for the management of vector-borne illnesses.