Related Experiment Video
Updated: May 20, 2025
Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses
Published on: September 11, 2023
Intraocular Tumor Biopsy
Khushboo Chauhan1, Arun Singh2, Vishal Raval1,3
1Ophthalmologist, Anant Bajaj Retina Institute, LV Prasad Eye Institute, Hyderabad, India.
Background:
Intraocular biopsy is a diagnostic procedure used to obtain tissue samples to identify intraocular lesions, including tumors, infections, and inflammatory conditions. Inconclusive clinical and imaging findings necessitate intraocular biopsy.
Methods:
This retrospective review reviewed the relevant literature, including relevant reviews, original articles, case reports, and case series published up to July 2024.
Results:
Depending on the location and suspected nature of the lesion, intraocular biopsy is performed using various techniques, such as fine-needle aspiration biopsy (FNAB), vitreous biopsy, and chorioretinal biopsy. Despite its challenges, such as small sample size and potential complications like retinal detachment and hemorrhage, intraocular biopsy plays a vital role in guiding management decisions, including treatment planning. Recent advancements in molecular pathology and imaging-guided biopsy techniques have enhanced tissue yield and safety, making biopsy an invaluable diagnostic tool. In ocular oncology, prognostic biopsy for uveal melanoma has become the standard of care.
Conclusion:
Intraocular biopsy remains a crucial diagnostic tool for treatment decision-making and improving patient outcomes. Technological advancements continue to refine its efficacy and safety, reinforcing its role in modern ophthalmic practice.
