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Updated: May 20, 2025

Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses

Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses

Published on: September 11, 2023

Intraocular Tumor Biopsy.

Khushboo Chauhan¹, Arun Singh², Vishal Raval^1,3

¹Ophthalmologist, Anant Bajaj Retina Institute, LV Prasad Eye Institute, Hyderabad, India.

Seminars in Ophthalmology

|March 25, 2025

Summary

This summary is machine-generated.

Intraocular biopsy is vital for diagnosing eye conditions when other methods fail. Advancements improve its safety and effectiveness for better patient outcomes.

Keywords:

Chorioretinal biopsy fine-needle aspiration biopsy intraocular biopsy intraocular tumors vitreous biopsy

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Area of Science:

Ophthalmology
Oncology
Pathology

Background:

Intraocular biopsy obtains tissue samples to diagnose eye lesions like tumors, infections, and inflammatory conditions.
It is essential when clinical and imaging findings are inconclusive.

Purpose of the Study:

To review the literature on intraocular biopsy techniques, applications, and advancements.
To highlight its role in diagnosis and treatment planning for intraocular lesions.

Main Methods:

Retrospective literature review up to July 2024.
Inclusion of reviews, original articles, case reports, and case series.

Main Results:

Various techniques exist, including fine-needle aspiration biopsy (FNAB), vitreous biopsy, and chorioretinal biopsy.
Despite challenges (small sample size, complications), it guides management and treatment.
Advancements in molecular pathology and imaging enhance yield and safety.
Prognostic biopsy for uveal melanoma is standard care in ocular oncology.

Conclusions:

Intraocular biopsy is crucial for treatment decisions and improving patient outcomes.
Technological progress enhances its efficacy and safety in ophthalmic practice.