Ecology, global diversity and evolutionary mechanisms in the Mycobacterium tuberculosis complex
Galo A Goig1,2, Etthel M Windels1,2,3,4, Chloé Loiseau1,2
1Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Allschwil, Switzerland.
Nature Reviews. Microbiology
|March 26, 2025
Summary
Tuberculosis (TB), caused by Mycobacterium tuberculosis complex (MTBC), remains a leading infectious killer. Genome sequencing advances reveal new insights into MTBC evolution, host adaptation, and drug resistance, aiding global TB control efforts.
Area of Science:
- Genomics
- Microbiology
- Evolutionary Biology
Background:
- Tuberculosis (TB) remains a significant global health threat, caused by the Mycobacterium tuberculosis complex (MTBC).
- Recent advancements in genomic sequencing offer novel perspectives on MTBC's ecology and evolution.
- Understanding MTBC is crucial for effective global TB control strategies.
Purpose of the Study:
- To review recent insights into the Mycobacterium tuberculosis complex (MTBC) gained through genomic sequencing.
- To discuss the implications of these findings for the global control of tuberculosis (TB).
Main Methods:
- Review of recent literature on MTBC genomics.
- Analysis of findings from genome sequencing studies, including long-read sequencing.
Main Results:
- Discovery of novel MTBC phylogenetic lineages.
- Enhanced understanding of host tropism in animal-adapted MTBC lineages.
- Improved knowledge of antimicrobial resistance evolution, transmission dynamics, and within-host MTBC diversity.
- Highlighting the importance of structural genomic variation in MTBC.
Conclusions:
- Genomic sequencing has significantly advanced our understanding of MTBC biology and epidemiology.
- These insights provide new avenues for research and inform strategies for global TB control.
More Related Videos
10:04Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
18.7K
09:34An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
1.7K
Related Concept Videos
01:28Pulmonary Tuberculosis II
202
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
202
01:29Pulmonary Tuberculosis I
212
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
212
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
01:31Pulmonary Tuberculosis III
282
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
282
01:28Pulmonary Tuberculosis V
159
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
159
01:26Pulmonary Tuberculosis IV
127
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
127