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Updated: May 20, 2025

Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System
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Migrasomes, critical players in intercellular communication.

Zhiyong Tan1,2,3, Chadanfeng Yang1,2,3, Shi Fu1,2,3

  • 1Department of Urology, Yunnan Institute of Urology, The Second Affiliated Hospital of Kunming Medical University, No. 347, Dianmian Street, Wuhua District, Kunming, Yunnan, 650101, People's Republic of China.

Cancer Cell International
|March 26, 2025
PubMed
Summary

Migrasomes, extracellular vesicles (EVs) from migrating cells, are key to cell communication. This review details their formation, function, and roles in health and disease.

Keywords:
Cell–cell communicationExtracellular vesiclesMigrasomePhysiological and pathological processes

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Area of Science:

  • Cell Biology
  • Extracellular Vesicles
  • Intercellular Communication

Background:

  • Migrasomes are novel extracellular vesicles (EVs) originating from migrating cells.
  • They contain proteins, lipids, and RNA, facilitating intercellular signaling.
  • Migrasomes are implicated in physiological and pathological processes.

Purpose of the Study:

  • To review the current understanding of migrasome biogenesis and release.
  • To summarize the known biological activities and functions of migrasomes.
  • To propose potential novel roles for migrasomes in cell communication.

Main Methods:

  • Literature review of recent studies on migrasomes.
  • Analysis of migrasome formation, release, and molecular cargo.
  • Synthesis of current evidence on migrasome involvement in physiological and pathological conditions.

Main Results:

  • Migrasomes are formed from retracting cellular fibers during migration.
  • They mediate intercellular communication by transferring molecular signals.
  • Migrasomes are involved in embryogenesis, angiogenesis, immune modulation, and mitochondrial quality control.
  • They are implicated in cancer metastasis, cardiovascular diseases, and viral infections.

Conclusions:

  • Understanding migrasome biogenesis and function is crucial for deciphering their role in cell-to-cell communication.
  • Migrasomes represent a significant area of research with broad implications in health and disease.
  • Further investigation into migrasome functions may uncover new therapeutic targets.