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Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice
Published on: March 1, 2017
[A NEW MULTIPLE SCLEROSIS DIAGNOSIS IN A PATIENT WITH INTERMEDIATE UVEITIS]
Tom Kozlovsky1, Idit Maharshak1, Asaf Bar1
1Ophthalmology Department, Wolfson Medical Center.
Introduction:
Uveitis is a group of about 30 intra-ocular inflammatory diseases; multiple sclerosis (MS) is an immune-mediated chronic inflammatory disease of the central nervous system (CNS). Intermediate uveitis has been reported to be the most common type of uveitis in association with MS. The mechanism associating MS and uveitis is not clear, but previous data suggest a genetic predisposition may play a role. In addition, MS patients presenting with uveitis prior to the onset of neurological symptoms tend to demonstrate a milder form of the disease with moderate progression. This observation may be attributed to early immunomodulatory treatment given to those patients to treat uveitis. We describe a female patient who was diagnosed with intermediate uveitis that was defined as undifferentiated; 9 years later, she was diagnosed with relapsing-remitting MS.
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