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Updated: May 20, 2025

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[VOGT-KOYANAGI-HARADA SYNDROME].

Dana Cohen1, Yael Ben-Arie-Weintrob2, Tamar Hareuveni-Blum3

  • 1Department of Ophthalmology, Galilee Medical Center, Nahariya.

Harefuah
|March 26, 2025
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Summary

Vogt-Koyanagi-Harada (VKH) syndrome, an autoimmune disease, can cause severe vision loss. Early diagnosis and treatment with steroids, immunosuppressants, and biologics are crucial for managing VKH complications.

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Immunology

Background:

  • Vogt-Koyanagi-Harada (VKH) syndrome is a rare autoimmune disorder causing pan-ocular inflammation.
  • It can lead to systemic symptoms like hearing loss and neurologic issues.
  • Chronic inflammation and flare-ups can cause significant vision loss.

Purpose of the Study:

  • To present a case report and literature review of Vogt-Koyanagi-Harada syndrome.
  • To discuss ocular and systemic manifestations, diagnosis, and treatment.
  • To highlight the importance of early intervention in VKH.

Main Methods:

  • Case report of a 14-year-old patient with bilateral granulomatous uveitis.
  • Comprehensive workup for infectious and rheumatologic diseases.
  • Literature review on VKH manifestations, diagnosis, and treatment.

Main Results:

  • The patient initially presented with uveitis and optic nerve/retinal edema.
  • Initial steroid treatment was insufficient, with subsequent imaging confirming VKH.
  • Treatment with immunosuppressants (Imuran, Cyclosporin) and biologics showed a good response.

Conclusions:

  • Early diagnosis and prompt, appropriate treatment are vital for VKH management.
  • Multifaceted treatment including immunosuppressants and biologics can effectively control VKH.
  • Minimizing ocular and extraocular complications requires timely and aggressive therapeutic strategies.