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Immunotherapy for hypertensive end-organ damage: a new therapeutic strategy

Zhiyang Xu1,2, Haisheng Yu1, Rulin Zhuang3

  • 1State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210000, China.

Essays in Biochemistry
|March 26, 2025
PubMed

Insights

Hypertension, a common chronic condition, is linked to premature death and involves complex factors including immune responses. Research explores immunotherapy as a promising treatment for hypertension-related organ damage.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Nephrology

Background:

  • Hypertension is a prevalent global health issue contributing significantly to premature mortality.
  • Its development involves intricate factors like age, genetics, and neuroendocrine activation.
  • Growing evidence highlights the role of autoimmune responses in hypertension and subsequent end-organ damage.

Purpose of the Study:

  • To investigate the role of immune cells in hypertension pathogenesis and end-organ damage.
  • To explore potential immunotherapy strategies for managing hypertension-induced complications.

Main Methods:

  • Review of current literature on immune cell involvement in hypertension.
  • Analysis of mechanisms by which immune cells contribute to vascular and organ damage.
  • Evaluation of emerging immunotherapy approaches for hypertension management.

Main Results:

  • Immune cells (innate and adaptive) infiltrate renal and vascular tissues in hypertension.
  • These cells release inflammatory mediators, reactive oxygen species, and metalloproteinases.
  • This process leads to vascular dysfunction and structural/functional damage in the heart and kidneys.

Conclusions:

  • Immune system activation is a critical factor in hypertension and its associated end-organ damage.
  • Immunotherapy presents a promising therapeutic avenue for managing hypertension and its sequelae.
  • Further research into targeted immunotherapies is warranted for effective intervention.

Keywords:
end-organ damagehypertensionimmune systemimmunomodulationimmunotherapy

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