Pulmonary extranodal NK/T-cell lymphoma: A clinicopathological analysis of five patients
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View abstract on PubMed
Summary
This summary is machine-generated.Extranodal natural killer (NK)/T-cell lymphoma (ENKTL) of the lung is aggressive and difficult to diagnose. Accurate diagnosis requires immunohistochemistry and Epstein-Barr virus (EBV)-encoded RNA (EBER) fluorescence in situ hybridization (FISH).
Area Of Science
- Oncology
- Hematology
- Pathology
Background
- Extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is a rare and aggressive non-Hodgkin lymphoma.
- Pulmonary involvement is uncommon, presenting diagnostic challenges due to varied histological features.
Purpose Of The Study
- To investigate the clinicopathological features of pulmonary ENKTL.
- To identify diagnostic markers and potential treatment strategies for pulmonary ENKTL.
Main Methods
- Retrospective analysis of five untreated pulmonary ENKTL cases.
- Evaluation of hematoxylin-eosin staining, immunohistochemistry (IHC), and Epstein-Barr virus-encoded ribonucleic acid (EBER) fluorescence in situ hybridization (FISH).
Main Results
- All five patients were diagnosed with stage IV disease.
- Tumor cells expressed CD3, T-cell intracellular antigen-1, and granzyme B; CD56 was positive in 4/5 cases.
- All cases were EBER-FISH positive, and the Ki-67 proliferation index was high (40-90%).
- Prognosis was poor, with a median survival of 3-24 months for chemotherapy patients and 1 month for supportive care only.
Conclusions
- Pulmonary ENKTL is an aggressive malignancy with a poor prognosis.
- Accurate diagnosis relies on IHC and EBER-FISH due to potential for misdiagnosis.
- Further research into effective treatment strategies is warranted.
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